Ndị injinia MIT haziri gluu dị ike, nke na-adakọbara ọnụ nke nwere ike mechie anụ ahụ merụrụ ahụ wee kwụsị ọbara ọgbụgba, nke sitere na ihe nnyapade nke barnacles na-eji na-arapara na nkume. Ebe E Si Nweta: foto ngwaahịa
Ihe nrapado ọhụrụ nke na-eṅomi ihe nnyapade nke barnacles na-eji na-arapara na nkume nwere ike inye ụzọ ka mma isi gwọọ ọnyá.
Site n'ike mmụọ nsọ site na ihe nnyapade nke barnacles na-eji na-arapara na nkume, ndị injinia MIT haziri gluu dị ike nke nwere ike mechie anụ ahụ merụrụ ahụ wee kwụsị ọbara ọgbụgba.
Ọ bụrụgodị na ọbara kpuchiri elu ya, mado ọhụrụ a nwere ike ịrapara n'elu ma nwee ike ịmepụta akara siri ike n'ime ihe dị ka 15 sekọnd ka etinyechara ya. Ndị nchọpụta na-ekwu na gluu a nwere ike inye ụzọ dị irè karị isi gwọọ mmerụ ahụ ma nyere aka ịchịkwa ọbara ọgbụgba n'oge ịwa ahụ.
"Anyị na-edozi nsogbu nke adhesion na gburugburu ebe a na-ama aka, ya bụ, iru mmiri na gburugburu ebe obibi siri ike nke anụ ahụ mmadụ. N'otu oge ahụ, anyị na-agbalị ịgbanwe ihe ọmụma ndị a bụ isi ka ọ bụrụ ezigbo ngwaahịa ndị nwere ike ịzọpụta ndụ," MIT Machinery kwuru Zhao Xuanhe, onye prọfesọ nke injinịa na injinia obodo na gburugburu ebe obibi na otu n'ime ndị edemede nke ọmụmụ ihe.
Christoph Nabzdyk bụ ọkachamara n'ọrịa obi na dọkịta na-ahụ maka nlekọta ahụike na Mayo Clinic na Rochester, Minnesota, na onye isi akwụkwọ akụkọ ahụ, nke e bipụtara na Nature Biomedical Engineering na August 9, 2021. MIT ọkà mmụta sayensị Hyunwoo Yuk na postdoctoral ibe Jingjing Wu bụ ndị isi dere ihe ọmụmụ.
Otu nyocha: Hyunwoo Yuk, Jingjing Wu, Xuanhe Zhao (site n'aka ekpe gaa n'aka nri), na-ejide shei barnacle na barnacle gum hemostatic ude n'aka. Ebe E Si Nweta: Onye nyocha nyere ya
Ịchọta ụzọ a ga-esi kwụsị ọbara ọgbụgba bụ nsogbu dịteworo aka, mana edozibeghị ya nke ọma, Zhao kwuru. A na-ejikarị sutures mechie ọnya, ma sutures bụ usoro na-ewe oge nke ndị na-aza ajụjụ mbụ na-emekarị enweghị ike ime na mberede. N'ime ndị agha, ọnwụ ọbara bụ isi ihe kpatara ọnwụ mgbe trauma gasịrị, ebe n'ozuzu mmadụ, ọnwụ ọbara bụ ihe nke abụọ na-akpata ọnwụ mgbe trauma gasịrị.
N'afọ ndị na-adịbeghị anya, ụfọdụ ihe nwere ike ịkwụsị ọbara ọgbụgba, nke a na-akpọkwa hemostatic agents, anọwo n'ahịa. Ọtụtụ n'ime ihe ndị a bụ patches nwere ihe na-eme ka ọbara na-akpụkọ ọnụ nke na-enyere aka ịchịkọta ọbara n'onwe ya. Agbanyeghị, ndị a na-ewe ọtụtụ nkeji iji mepụta akara na ọ naghị arụ ọrụ mgbe niile na ọnya na-agba ọbara.
Ụlọ nyocha nke Zhao agba mbọ na-edozi nsogbu a kemgbe ọtụtụ afọ. N'afọ 2019, ndị otu ya mepụtara teepu anụ ahụ nwere akụkụ abụọ wee gosi na enwere ike iji ya mechie mbepụ ịwa ahụ. Ihe na-akpali akpali nke teepu a bụ ihe nnyapade nke spiders ji ejide anụ oriri n'ọnọdụ iru mmiri. Ọ nwere polysaccharides ebubo nke nwere ike ịmịnye mmiri n'elu ihe fọrọ nke nta ka ọ bụrụ ozugbo, na-ewepụ obere ntụpọ akọrọ nke gluu nwere ike ịrapara na ya.
Maka gluu anụ ahụ ọhụrụ ha, ndị nchọpụta ahụ nwetara mmụọ nsọ ọzọ site na okike. N'oge a, ha lekwasịrị anya na barnacles, nke bụ obere crustaceans jikọtara na anụmanụ ndị ọzọ dị ka nkume, ụgbọ mmiri na ọbụna whale. Ebe ndị a na-adị mmiri ma na-adịkarị unyi - ọnọdụ ndị a na-eme ka nrapado sie ike.
Yuk kwuru, sị: “Nke a dọọrọ uche anyị. "Nke a na-adọrọ mmasị nke ukwuu, n'ihi na iji mechie anụ ahụ na-agba ọbara, ị ga-emerịrị ọ bụghị naanị mmiri mmiri, kamakwa mmetọ nke ọbara na-asọpụta. Anyị chọpụtara na ihe a e kere eke bi na gburugburu mmiri na-eme kpọmkwem otu ihe ahụ anyị ga-eme iji nagide ya. Nsogbu ọbara ọgbụgba dị mgbagwoju anya. "
Nyocha nke ndị nyocha banyere chịngọm barnacle na-egosi na o nwere ihe mejupụtara ya pụrụ iche. Mkpụrụ ndụ protein ndị na-egbuke egbuke nke na-enyere barnacle aka ịgbanye n'elu na-akwụsịtụ n'ụdị mmanụ, nke nwere ike ịchụpụ mmiri na ihe ọ bụla na-emerụ ahụ dị n'elu, nke mere na protein ahụ na-egbuke egbuke na-ejikọta ya na elu.
Ndị otu MIT kpebiri ịgbalị iṅomi gluu a site n'ịgbanwe ihe nrapado ha mepụtara na mbụ. Ihe viscous a nwere polymer nke a na-akpọ poly(acrylic acid) bụ nke etinyere n'ime ya bụ ngwakọta organic a na-akpọ NHS ester iji nye adhesion, ebe chitosan bụ shuga na-eme ka ihe ahụ sie ike. Ndị na-eme nchọpụta na-ekpochapụ flakes nke ihe a, na-egweri ha n'ime ụmụ irighiri ihe, wee kwụsịtụ ihe ndị a na mmanụ silicone ọkwa ahụike.
Mgbe a na-etinye tapawa nke na-esi na ya pụta n'elu mmiri (dị ka anụ ahụ kpuchiri ọbara), mmanụ ahụ ga-achụpụ ọbara na ihe ndị ọzọ nwere ike ịdị, na-eme ka ụmụ irighiri ihe ndị dị na viscous na-agafe ma mee ka ọ bụrụ ihe siri ike na ọnya ahụ. Nlele ndị nchọpụta mere na ụmụ oke gosiri na n'ime sekọnd 15 ruo 30 ka ha tinyechara gluu, jiri nwayọọ tinye nrụgide, gluu na-esiwanye ike ma kwụsị ọbara ọgbụgba.
Ndị ọrụ nyocha ahụ kwuru na atụnyere teepu nwere akụkụ abụọ nke ndị nyocha haziri na 2019, otu uru nke ihe ọhụrụ a bụ na enwere ike ịkpụzi tapawa ahụ ka ọ dabara na ọnya na-adịghị ahụkebe, na teepu nwere ike dabara adaba maka ịwa ahụ akara Mee nbibi ma ọ bụ tinye ngwaọrụ ahụike na anụ ahụ. Wu kwuru, "Tapawa a na-agbanwe agbanwe nwere ike ịbanye n'ime ma dabara n'ụdị ọ bụla na-adịghị agafe agafe," Wu kwuru. "Nke a na-enye ndị ọrụ ohere ime mgbanwe maka ọnya ọbara ọgbụgba dị iche iche na-adịghị agbanwe agbanwe."
N'ime ule ndị e mere na ezì, Nabzdyk na ndị ọrụ ibe ya na Mayo Clinic chọpụtara na gluu a nwere ike ịkwụsị ọbara ọgbụgba ngwa ngwa, nakwa na ọ na-arụ ọrụ ngwa ngwa na nke ọma karịa onye na-ahụ maka hemostatic dị na-ere ahịa ha tụnyere. Ọ nwedịrị ike ịrụ ọrụ mgbe ọ na-enye ezì ka ọ na-eme ka ọbara dị ike (heparin) ka ọbara ghara ịmịkọta ya ozugbo.
Nnyocha ha na-egosi na akara ahụ na-adịgide ruo ọtụtụ izu, na-enye ohere maka anụ ahụ iji gwọọ onwe ya, na gluu na-akpata obere mbufụt, dị ka nsị nke ndị na-ahụ maka hemostatic na-eji ugbu a. Glu ga-eji nwayọọ nwayọọ banye n'ime ahụ n'ime ọnwa ole na ole. Ọ bụrụ na dọkịta na-awa ahụ kwesịrị ịrụzi ọnya ahụ mgbe ngwa mbụ ahụ gasịrị, a pụkwara iwepụ ya n'ọdịnihu site na iji ngwọta na-agbaze ya.
Ndị nchọpụta ahụ na-eme atụmatụ ugbu a ịnwale gluu na nnukwu ọnya, ha na-atụkwa anya na nke a ga-egosi na a pụrụ iji gluu na-agwọ ọnyá. Ha chekwara na ọ nwere ike ịba uru n'oge ịwa ahụ, nke na-achọkarị ka dọkịta na-awa ahụ na-etinye oge dị ukwuu n'ịchịkwa ọbara ọgbụgba.
Nabzdyk kwuru, "Anyị nwere ike na teknụzụ ịme ọtụtụ ịwa ahụ dị mgbagwoju anya, mana ike anyị ijikwa ngwa ngwa chịkwaa ọbara ọgbụgba siri ike emebeghị nke ọma," Nabzdyk kwuru.
Ngwa ọzọ enwere ike ime bụ inye aka kwụsị ọbara ọgbụgba. Ndị ọrịa a nwere tubes rọba etinyere n'ime arịa ọbara ha, dị ka nke a na-eji maka akwara akwara ma ọ bụ etiti venous catheters ma ọ bụ extracorporeal membrane oxygenation (ECMO). N'oge ECMO, a na-eji igwe na-ebupụ ọbara onye ọrịa n'ime ahụ iji nye ya oxygen. A na-eji ya agwọ ndị nwere oke obi ma ọ bụ ngụgụ. A na-etinyekarị tube ahụ ruo ọtụtụ izu ma ọ bụ ọnwa, na ọbara ọgbụgba na ebe ntinye nwere ike ibute ọrịa.
Ntụgharị aka: "Tapawa sitere na chịngọm chịngọm maka ịgbanye ọbara ngwa ngwa na nke na-adabere na coagulation" Ndị ode akwụkwọ: Hyunwoo Yuk, Jingjing Wu, Tiffany L. Sarrafian, Xinyu Mao, Claudia E. Varela, Ellen T. Roche, Leigh G. Griffiths, Christoph S Nabzdyk na Xuanhe Zhao, 9 Ọgọst 2021, Nature Biomedical Engineering.DOI: 10.1038/s41551-021-00769-y
Ndị nyocha ahụ enwetala ego n'aka MIT Deshpande Center iji nyere ha aka ịzụ ahịa gluu, nke ha nwere olile anya imezu mgbe ọmụmụ ihe izizi ọzọ gbasara ụdị anụmanụ. Nchọpụta ahụ nwetakwara ego sitere na National Institutes of Health, National Science Foundation, na Office of Army Research site na Soldier Nanotechnology Institute na Massachusetts Institute of Technology na Zoll Foundation.
Biko, biko zụọ ahịa ya ozugbo enwere ike. Nwunye m jiri gluu mechie ọnya m. Na-agba dị ka hell. Ọfọn, ikekwe m bụ nwa ọhụrụ, dị ka o kwuru mgbe ọ bụla o tinyere akwụkwọ.
SciTechDaily: Ụlọ kacha mma nke akụkọ sayensị na teknụzụ kemgbe 1998. Na-emelite akụkọ teknụzụ kachasị ọhụrụ site na email ma ọ bụ mgbasa ozi ọha.
Ọmụmụ nke ndị ọrịa nde 6.2 nke Kaiser Permanente na ndị nyocha CDC ga-aga n'ihu ruo afọ 2. Ndị ọrụ nyocha sitere na ụlọ ọrụ ahụike Federal na Caesars na-agbakọ ndekọ ahụike…
Oge nzipu: Sep-09-2021